Palladium(0)-Catalyzed Intramolecular Decarboxylative Allylation of Ortho Nitrobenzoic Esters
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- 作者：Asik Hossian ; Shantanu Singha ; Ranjan Jana
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：August 1, 2014
- 年：2014
- 卷：16
- 期：15
- 页码：3934-3937
- 全文大小：311K
- ISSN：1523-7052
文摘
A Pd/Ag bimetallic system has been developed for the decarboxylative allylation of ortho-nitrobenzoic esters in an intramolecular fashion. In contrast to the typical sp2鈥搒p3 cross-coupling approach which requires air and moisture sensitive preformed organometallic reagents, we provide an alternative route to the synthesis of ortho-allyl nitroarenes from the corresponding ortho-nitrobenzoic acid derivatives. The reaction proceeds through a mechanistically distinct decarboxylative metalation pathway. A cooperative reactivity of palladium and silver is crucial for the reaction outcome.