Macromolecular Ion Accelerator

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• 作者：Yun-Fei Hsu ; Jung-Lee Lin ; Szu-Hsueh Lai ; Ming-Lee Chu ; Yi-Sheng Wang ; Chung-Hsuan Chen
• 刊名：Analytical Chemistry
• 出版年：2012
• 出版时间：July 3, 2012
• 年：2012
• 卷：84
• 期：13
• 页码：5765-5769
• 全文大小：324K
• 年卷期：v.84,no.13(July 3, 2012)
• ISSN：1520-6882

文摘

Presented herein are the development of macromolecular ion accelerator (MIA) and the results obtained by MIA. This new instrument utilizes a consecutive series of planar electrodes for the purpose of facilitating stepwise acceleration. Matrix-assisted laser desorption/ionization (MALDI) is employed to generate singly charged macromolecular ions. A regular Z-gap microchannel plate (MCP) detector is mounted at the end of the accelerator to record the ion signals. In this work, we demonstrated the detection of ions with the mass-to-charge (m/z) ratio reaching 30鈥?00鈥?00. Moreover, we showed that singly charged biomolecular ions can be accelerated with the voltage approaching 1 MV, offering the evidence that macromolecular ions can possess much higher kinetic energy than ever before.