Chlorabietols A鈥揅, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii

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• 作者：Juan Xiong ; Zhi-Lai Hong ; Li-Xin Gao ; Jie Shen ; Shu-Ting Liu ; Guo-Xun Yang ; Jia Li ; Huaqiang Zeng ; Jin-Feng Hu
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：80
• 期：21
• 页码：11080-11085
• 全文大小：297K
• ISSN：1520-6904

文摘

Three unprecedented phloroglucinol-diterpene adducts, chlorabietols A鈥揅 (1鈥?b>3), were isolated from the roots of the rare Chloranthaceae plant Chloranthus oldhamii. They represent a new class of compounds, featuring an abietane-type diterpenoid coupled with different alkenyl phloroglucinol units by forming a 2,3-dihydrofuran ring. Their structures were elucidated by detailed spectroscopic analysis, molecular modeling studies, and electronic circular dichroism calculations. Compounds 1鈥?b>3 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC₅₀ values of 12.6, 5.3, and 4.9 渭M, respectively.