Full Surface Embedding of Gold Clusters on Silicon Nanowires for Efficient Capture and Photothermal Therapy of Circulating Tumor Cells

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• 作者：Gyeong-Su Park ; Hyuksang Kwon ; Dong Wook Kwak ; Seong Yong Park ; Minseok Kim ; Jun-Ho Lee ; Hyouksoo Han ; Sung Heo ; Xiang Shu Li ; Jae Hak Lee ; Young Hwan Kim ; Jeong-Gun Lee ; Woochul Yang ; Hoon Young Cho ; Seong Keun Kim ; Kinam Kim
• 刊名：Nano Letters
• 出版年：2012
• 出版时间：March 14, 2012
• 年：2012
• 卷：12
• 期：3
• 页码：1638-1642
• 全文大小：447K
• 年卷期：v.12,no.3(March 14, 2012)
• ISSN：1530-6992

文摘

We report on rapid thermal chemical vapor deposition growth of silicon nanowires (Si NWs) that contain a high density of gold nanoclusters (Au NCs) with a uniform coverage over the entire length of the nanowire sidewalls. The Au NC-coated Si NWs with an antibody-coated surface obtain the unique capability to capture breast cancer cells at twice the highest efficiency currently achievable (88% at 40 min cell incubation time) from a nanostructured substrate. We also found that irradiation of breast cancer cells captured on Au NC-coated Si NWs with a near-infrared light resulted in a high mortality rate of these cancer cells, raising a fine prospect for simultaneous capture and plasmonic photothermal therapy for circulating tumor cells.

Keywords:

Si nanowire; RTCVD; gold nanocluster; breast cancer cells; photothermal therapy