Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells

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• 作者：Qinghao Jin ; Jin Woo Lee ; Hari Jang ; Ji Eun Choi ; Dongho Lee ; Jin Tae Hong ; Youngsoo Kim ; Mi Kyeong Lee ; Bang Yeon Hwang
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：June 24, 2016
• 年：2016
• 卷：79
• 期：6
• 页码：1548-1553
• 全文大小：325K
• 年卷期：0
• ISSN：1520-6025

文摘

Eight new sesquiterpenes (1–8), along with seven known sesquiterpenes (9–15), were isolated from a methanol extract of the flowers of Inula japonica. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. All of isolates were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 cells, with their IC₅₀ values ranging from 1.9 to 15.4 μM.