Constituents of Oxandra cf. xylopioides with Anti-inflammatory Activity

详细信息    查看全文

• 作者：Benjamin Rojano ; Edwin Pé ; rez ; Bruno Figadè ; re ; Marie Thé ; rè ; se Martin ; Mar&iacute ; a C. Recio ; Rosa Giner ; José ; L. R&iacute ; os ; Guillermo Schinella ; Jairo Sá ; ez
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：May 2007
• 年：2007
• 卷：70
• 期：5
• 页码：835 - 838
• 全文大小：80K
• 年卷期：v.70,no.5(May 2007)
• ISSN：1520-6025

文摘

A new triterpenoid (1) derived from 24-methylcycloartanol was isolated from the leaves of Oxandra cf. xylopioides. Anunusual structure of the new compound was assigned as 1, for which the name berenjenol is proposed, on the basis ofthe spectroscopic data of the natural product and of its derivatives 2 and 3. The leaves also afforded the knownmonoterpene isoespintanol (4). Compounds 1 and 4 significantly reduced the paw edema induced by carrageenan by64% and 43%, at 3 h, respectively. Moreover, 4 reduced IL-1 production by 72% at 100 M and reduced IL-1mRNA synthesis.