Oxidized Multiwalled Carbon Nanotubes as Antigen Delivery System to Promote Superior CD8+ T Cell Response and Protection against Cancer
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- 作者：Paula Cristina Batista de Faria ; Luara Isabela dos Santos ; Jo茫o Paulo Coelho ; Henrique B眉cker Ribeiro ; Marcos Assun莽茫o Pimenta ; Luiz Orlando Ladeira ; Dawidson Assis Gomes ; Clasc铆dia Aparecida Furtado ; Ricardo Tostes Gazzinelli
- 刊名：Nano Letters
- 出版年：2014
- 出版时间：September 10, 2014
- 年：2014
- 卷：14
- 期：9
- 页码：5458-5470
- 全文大小：735K
- ISSN：1530-6992
文摘
Properties like high interfacial area with cellular membranes, unique ability to incorporate multiple functionalization, as well as compatibility and transport in biological fluids make carbon nanotubes (CNTs) useful for a variety of therapeutic and drug-delivery applications. Here we used a totally synthetic hybrid supramolecule as an anticancer vaccine formulation. This complex structure comprises CNTs as delivery system for the Cancer Testis Antigen named NY-ESO-1, allied to a synthetic Toll-Like Receptor agonist. The CNT constructs were rapidly internalized into dendritic cells, both in vitro and in vivo, and served as an intracellular antigen depot. This property favored the induction of strong CD4+ T as well as CD8+ T cell-mediated immune responses against the NY-ESO-1. Importantly, the vaccination significantly delayed the tumor development and prolonged the mice survival, highlighting the potential application of CNTs as a vaccine delivery system to provide superior immunogenicity and strong protection against cancer.