Self-Adjuvanting Polymer鈥揚eptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer
详细信息 查看全文
- 作者：Tzu-Yu Liu ; Waleed M. Hussein ; Zhongfan Jia ; Zyta M. Ziora ; Nigel A. J. McMillan ; Michael J. Monteiro ; Istvan Toth ; Mariusz Skwarczynski
- 刊名：Biomacromolecules
- 出版年：2013
- 出版时间：August 12, 2013
- 年：2013
- 卷：14
- 期：8
- 页码：2798-2806
- 全文大小：420K
- 年卷期：v.14,no.8(August 12, 2013)
- ISSN：1526-4602
文摘
Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.