Suppressive Effects of Ethanolic Extracts from Propolis and Its Main Botanical Origin on Dioxin Toxicity

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• 作者：Yong K. Park ; Itsuko Fukuda ; Hitoshi Ashida ; Shin Nishiumi ; Ken-ichi Yoshida ; Andreas Daugsch ; Helia H. Sato ; and Glaucia M. Pastore
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2005
• 出版时间：December 28, 2005
• 年：2005
• 卷：53
• 期：26
• 页码：10306 - 10309
• 全文大小：100K
• 年卷期：v.53,no.26(December 28, 2005)
• ISSN：1520-5118

文摘

Suppressive effects of ethanolic extracts prepared from propolis group 12 and its main botanicalorigin (leaf bud of Baccharis dracunculifolia) on transformation of the aryl hydrocarbon receptor (AhR),the initial action of dioxin toxicity, were investigated. It was found that suppressive effects of propolison AhR transformation were relatively higher than those of resins of its botanical origin in cell-freesystem and in Hepa-1c1c7 cells. When the composition of chemical ingredients was measured,propolis contained slightly higher amounts of flavonoid aglycones as compared with its botanicalorigin with the same characteristics. Moreover, antiradical activity, one of the typical biological activitiesof flavonoids, in propolis was also slightly higher than that in its botanical origin. These results indicatethat not only propolis but also its botanical origin contains high amounts of flavonoid aglycones andthat both of them are useful dietary sources for flavonoids with a potency to prevent dioxin toxicity.Keywords: Propolis; Baccharis dracunculifolia; flavonoid; dioxin; TCDD; aryl hydrocarbon receptor