Synthesis of Rigid Homo- and Heteroditopic Nucleobase-Terminated Molecules Incorporating Adenine and/or Thymine

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• 作者：Mikkel F. Jacobsen ; Casper S. Andersen ; Martin M. Knudsen ; Kurt V. Gothelf
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：July 19, 2007
• 年：2007
• 卷：9
• 期：15
• 页码：2851 - 2854
• 全文大小：138K
• 年卷期：v.9,no.15(July 19, 2007)
• ISSN：1523-7052

文摘

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A series of homo- and heteroditopic thymine- and/or adenine-terminated molecules incorporating rigid aryl or oligo(phenylene ethynylene)linkers has been efficiently synthesized. The key steps involved in the synthesis are the construction of the N-arylated nucleobases using theChan-Lam-Evans-modified Ullman coupling and their further elaboration using the Sonogashira coupling. Furthermore, the synthesis of arigid tripodal thymine derivative is reported.