Palladium-Catalyzed Dehydrative Cross-Coupling of Allylic Alcohols and N-Heterocycles Promoted by a Bicyclic Bridgehead Phosphoramidite Ligand and an Acid Additive
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- 作者：Kyungjun Kang ; Jaewook Kim ; Ansoo Lee ; Woo Youn Kim ; Hyunwoo Kim
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：February 5, 2016
- 年：2016
- 卷：18
- 期：3
- 页码：616-619
- 全文大小：390K
- ISSN：1523-7052
文摘
A mild and efficient dehydrative cross-coupling reaction between allylic alcohols and N-heterocycles using palladium catalysis is reported. A bicyclic bridgehead phosphoramidite (briphos) ligand together with Pd(dba)2 is a highly efficient catalyst, and an acid additive involved in the rate-determining step promotes the catalytic cycle. The coupling reaction of allylic alcohols with N-heterocycles including imidazoles, benzimidazoles, and triazole proceeds under mild reaction conditions with high yields using Pd/briphos and pentafluorophenol.