Identification and Synthesis of an Oxidation Product of Tilmicosin
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- 作者：Kevin E. Willard ; Herbert A. Kirst ; James P. Leeds ; Robin S. Readnour ; Paul R. Klink ; Christine M. Cleveland ; and Douglas E. Kiehl
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：1998
- 出版时间：August 1998
- 年：1998
- 卷：46
- 期：8
- 页码：3265 - 3271
- 全文大小：182K
- 年卷期：v.46,no.8(August 1998)
- ISSN：1520-5118
文摘
During formulation development of the veterinary macrolide antibiotic tilmicosin, an oxidationproduct of the parent molecule was identified. Use of liquid chromatography/mass spectrometryand nuclear magnetic resonance spectroscopy characterized the structure as 12,13-epoxytilmicosin,resulting from the oxidation of the double bond at the 12,13-position of the macrolide dienone. Thesynthesis of this oxidation product for confirmation of structural identity is described. The syntheticcompound was identical to the isolated oxidation product, 12,13-epoxytilmicosin.Keywords: Tilmicosin; epoxytilmicosin; macrolide; oxidation; synthesis; liquid chromatography/ion spray mass spectrometry