Total Synthesis of Chivosazole F

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• 作者：Tobias Brodmann ; Dominic Janssen ; Markus Kalesse
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：October 6, 2010
• 年：2010
• 卷：132
• 期：39
• 页码：13610-13611
• 全文大小：180K
• 年卷期：v.132,no.39(October 6, 2010)
• ISSN：1520-5126

文摘

The first synthesis of the highly biologically active chivosazole F is described. It features an intramolecular Stille coupling for the macrolactone formation and thereby circumvents the problem of isomerization associated with the tetraene segment. Additionally, the synthesis confirms the structure which has been proposed based solely on a combination of NMR/computational methods and genetic analysis.