Enantioselective Annulations for Dihydroquinolones by in Situ Generation of Azolium Enolates
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- 作者：Anna Lee ; Ashkaan Younai ; Christopher K. Price ; Javier Izquierdo ; Rama K. Mishra ; Karl A. Scheidt
- 刊名：Journal of the American Chemical Society
- 出版年：2014
- 出版时间：July 30, 2014
- 年：2014
- 卷：136
- 期：30
- 页码：10589-10592
- 全文大小：354K
- ISSN：1520-5126
文摘
A convergent, catalytic asymmetric formal [4 + 2] annulation for the synthesis of dihydroquinolones has been developed. Carboxylic acids can be employed as precursors to NHC enolates through an in situ activation strategy. Simultaneous generation of a reactive aza-o-quinone methide under the basic conditions employed for NHC generation leads to a dual activation approach.