Multivalent Protein Binding and Precipitation by Self-Assembling Molecules on a DNA Pentaplex Scaffold

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• 作者：Brooke A. Rosenzweig ; Nathan T. Ross ; Debarati M. Tagore ; Janarthanan Jayawickramarajah ; Ishu Saraogi ; Andrew D. Hamilton
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：April 15, 2009
• 年：2009
• 卷：131
• 期：14
• 页码：5020-5021
• 全文大小：165K
• 年卷期：v.131,no.14(April 15, 2009)
• ISSN：1520-5126

文摘

A supramolecular assembly containing an isoguanosine pentaplex with both a “protein-binding” face and a “reporter” face has been generated. When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule implicated in inflammation and heart disease.