Synthetic Viruslike Particles for Targeted Gene Delivery to αvβ3 Integrin-Presenting Endothelial Cells
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- 作者：Guy Zuber ; Monique Dontenwill ; Jean-Paul Behr
- 刊名：Molecular Pharmaceutics
- 出版年：2009
- 出版时间：October 5, 2009
- 年：2009
- 卷：6
- 期：5
- 页码：1544-1552
- 全文大小：318K
- 年卷期：v.6,no.5(October 5, 2009)
- ISSN：1543-8392
文摘
Progress in the design of gene delivery systems is of utmost importance for cancer gene therapy since several physiological and intracellular barriers remain. We previously developed a technology for condensing a single gene into a single and stable globular nanometric system. In this manuscript, we have decorated the nanometric particles with cyclic RGD ligands in order to target endothelial cells. The potential of these artificial viruses as targeted gene delivery vehicles is demonstrated in vitro with αvβ3 integrin-expressing primary endothelial cells.