A Nonpeptidic Reverse-Turn Scaffold Stabilized by Urea-Based Dual Intramolecular Hydrogen Bonding

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• 作者：Amiya K. Medda ; Chul Min Park ; Aram Jeon ; Hyunwoo Kim ; Jeong-Hun Sohn ; Hee-Seung Lee
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：July 1, 2011
• 年：2011
• 卷：13
• 期：13
• 页码：3486-3489
• 全文大小：735K
• 年卷期：v.13,no.13(July 1, 2011)
• ISSN：1523-7052

文摘

A novel nonpeptidic reverse-turn scaffold containing urea fragments that are connected by a conformationally constrained d-prolyl-cis-1,2-diaminocyclohexane (d-Pro-DACH) linker is reported. The scaffold adopts a well-defined reverse-turn conformation that is stabilized by dual intramolecular hydrogen bonding in both solution and solid states.