Inhibitors of Osteoclast Differentiation from Cephalotaxus koreana

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• 作者：Kee Dong Yoon ; Doc Gyun Jeong ; Yun Ha Hwang ; Jei Man Ryu ; Jinwoong Kim
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：70
• 期：12
• 页码：2029 - 2032
• 全文大小：87K
• 年卷期：v.70,no.12(December 2007)
• ISSN：1520-6025

文摘

Three new flavonoid glycosides (1–3), 11-hydroxyhainanolidol (4), and a new dibenzylbutyrolactone lignan glycoside (5) were isolated from the aerial parts of Cephalotaxus koreana Nakai, along with 19 known flavonoids. The structures of the new compounds were elucidated using spectroscopic evidence, primarily NMR and MS. Twenty-four compounds were isolated, and among these isoscutellarein 5-O-β-D-glucopyranoside (3), apigenin (6), kaempferol 3-O-α-L-rhamnopyranosyl(1′′′→6″)-β-D-glucopyranoside (7), tamarixetin 3-O-α-L-rhamnopyranosyl(1′′′→6″)-β-D-glucopyranoside (8), quercetin 3-O-[6″-O-acetyl]-β-D-glucopyranoside (9), and quercetin 3-O-α-L-rhamnopyranoside (10) showed significant inhibitory activities against osteoclast differentiation at concentrations of 0.1 and 1.0 µg/mL.