Yaoshanenolides A and B: New Spirolactones from the Bark of Machilus yaoshansis

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• 作者：Mingtao Liu ; Sheng Lin ; Maoluo Gan ; Minghua Chen ; Li Li ; Sujuan Wang ; Jiachen Zi ; Xiaona Fan ; Ying Liu ; Yikang Si ; Yongchun Yang ; Xiaoguang Chen ; Jiangong Shi
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：February 17, 2012
• 年：2012
• 卷：14
• 期：4
• 页码：1004-1007
• 全文大小：217K
• 年卷期：v.14,no.4(February 17, 2012)
• ISSN：1523-7052

文摘

Two novel tricyclic spirolactones bearing long linear alkyl chains, yaoshanenolides A (1) and B (2), formed by Diels鈥揂lder[4 + 2] cycloaddition of a molecule of each butenolide with 尾-phellandrene, were isolated from the bark of Machilus yaoshansis. Their structures and absolute configurations were determined by extensive spectroscopic methods, especially 2D NMR and ECD data analysis. The proposed biosynthetic pathway is discussed. Both compounds exhibited nonselective cytotoxic activities against several human cancer cell lines.