Dammarane Glycosides from the Root of Machilus yaoshansis

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• 作者：Maoluo Gan ; Mingtao Liu ; Lishe Gan ; Sheng Lin ; Bo Liu ; Yanling Zhang ; Jiachen Zi ; Weixia Song ; Jiangong Shi
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：July 27, 2012
• 年：2012
• 卷：75
• 期：7
• 页码：1373-1382
• 全文大小：342K
• 年卷期：v.75,no.7(July 27, 2012)
• ISSN：1520-6025

文摘

Nine new dammarane triterpene glycosides (1鈥?b>3 and 8鈥?b>13) and 12 known analogues have been isolated from an ethanol extract of the roots of Machilus yaoshansis. Compounds 1鈥?b>7 have an uncommon 20,23-dihydroxydammar-24-en-21-oic acid-21,23-lactone moiety that was previously reported in compounds isolated from Gynostemma pentaphyllum. The configurations of the lactone moieties in 1鈥?b>3 were determined by comparison of the experimental ECD spectra of 1鈥?b>3 and the hydrolysates, 1a and 1b, with the corresponding calculated ECD spectra. On the basis of NMR and ECD data analysis of 1鈥?b>7, the previously reported C-20 and C-23 configurations of 4鈥?b>7 and related derivatives from Gynostemma pentaphyllum were revised. In addition, the application of NMR data and Cotton effects to the determination of the relative and absolute configurations of the 纬-lactone moiety in 3尾,20,23-trihydroxydammar-24-en-21-oic acid-21,23-lactone derivatives is discussed.