High-Pressure Gas Phase Femtosecond Laser Ionization Mass Spectrometry

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• 作者：Jiahui Peng ; Noah Puskas ; Paul B. Corkum ; David M. Rayner ; Alexandre V. Loboda
• 刊名：Analytical Chemistry
• 出版年：2012
• 出版时间：July 3, 2012
• 年：2012
• 卷：84
• 期：13
• 页码：5633-5640
• 全文大小：314K
• 年卷期：v.84,no.13(July 3, 2012)
• ISSN：1520-6882

文摘

We describe a novel ion source for analytical mass spectrometry based on femtosecond laser ionization at pressures at and above atmospheric and characterize its performance when coupled to a tandem quadrupole/time-of-flight mass spectrometer. We assess source saturation limits, ionization and sampling efficiencies, the effective ionization volume, and limits of detection. We demonstrate 100% efficient ionization for a set of organic compounds and show that the degree of ion fragmentation over a range of laser powers is favorable compared to electron impact ionization, especially in that a substantial parent ion signal is always observed. We show how collisional cooling plays a role in controlling fragmentation at high pressures and address how ion鈥搈olecule chemistry can be controlled or exploited. High-pressure femtosecond laser ionization will allow 鈥渦niversal鈥?and efficient ionization, presenting a research direction that will broaden the options for gas phase analysis beyond the capabilities of electron impact ionization.