Catalytic Dual 1,1-H-Abstraction/Insertion for Domino Spirocyclizations

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• 作者：Jiang-Kai Qiu ; Bo Jiang ; Yi-Long Zhu ; Wen-Juan Hao ; De-Cai Wang ; Jun Sun ; Ping Wei ; Shu-Jiang Tu ; Guigen Li
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：July 22, 2015
• 年：2015
• 卷：137
• 期：28
• 页码：8928-8931
• 全文大小：473K
• ISSN：1520-5126

文摘

A catalytic domino spirocyclization of 1,7-enynes with simple cycloalkanes and cyclo-1,3-dicarbonyls has been established via multiple C鈥揅 bond formations from alkynyl/alkenyl functions and dual 伪,伪-C(sp³)-H abstraction/insertion. The reaction involves addition, 6-exo-dig cyclization and radical coupling sequences under convenient catalytic conditions and provides a concise access to spiro cyclopenta[c]quinolines in good to excellent yields.