Copper-Catalyzed Diazo Cross-/Homo-Coupling toward Tetrasubstituted Olefins and Applications on the Synthesis of Maleimide Derivatives
详细信息 查看全文
- 作者：Chenghao Zhu ; Guangyang Xu ; Dong Ding ; Lin Qiu ; Jiangtao Sun
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：September 4, 2015
- 年：2015
- 卷：17
- 期：17
- 页码：4244-4247
- 全文大小：444K
- ISSN：1523-7052
文摘
A challenging selective intermolecular cross-coupling and homocoupling of aryl鈥揳ryl or aryl鈥揳lkyl diazo compounds has been accomplished via a copper system, which afforded tetrasubstituted olefins in moderate to high yields with good to excellent Z-selectivity. This novel methodology enables rapid synthesis of tetrasubstituted olefins, which would find broad application in accessing maleimide libraries of nature products and bioactive small molecules.