Synthesis of 伪,伪-Disulfenylated Aldehydes via Oxidative Transformation of Tertiary Amines

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• 作者：Xin Huang ; Jichao Wang ; Zhangqin Ni ; Sichang Wang ; Yuanjiang Pan
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 6, 2015
• 年：2015
• 卷：17
• 期：21
• 页码：5488-5491
• 全文大小：342K
• ISSN：1523-7052

文摘

A method for the copper-catalyzed regioselective 尾-functionalization of tertiary amines with thiophenols has been developed. The control experiments and primary studies show that a thiyl radical is involved in the reaction, and the method provides a novel and direct approach to synthesize C(sp³)鈥揝 bonds without a directing group under ligand-free conditions.