A Novel, Facile Approach to Frondosin B and 5-epi-Liphagal via a New [4 + 3]-Cycloaddition

详细信息    查看全文

• 作者：Jie Zhang ; Liqi Li ; Yongxiang Wang ; Wenjing Wang ; Jijun Xue ; Ying Li
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：September 7, 2012
• 年：2012
• 卷：14
• 期：17
• 页码：4528-4530
• 全文大小：253K
• 年卷期：v.14,no.17(September 7, 2012)
• ISSN：1523-7052

文摘

A new [4 + 3]-cycloaddition between benzofuran allylic alcohols and dienes, promoted by camphorsulfonic acid, has been identified. A novel strategy which used this cycloaddition as a key step has been developed for the synthesis of 6,7,5-tricyclic skeleta, and syntheses toward frondosin B (1) and 5-epi-liphagal (2) have been achieved via short routes in good yields.