Copper-Catalyzed Hydroxyl-Directed Aminoarylation of Alkynes
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- 作者：Jiaqiong Sun ; Guangfan Zheng ; Tao Xiong ; Qiao Zhang ; Jinbo Zhao ; Yan Li ; Qian Zhang
- 刊名：ACS Catalysis
- 出版年：2016
- 出版时间：June 3, 2016
- 年：2016
- 卷：6
- 期：6
- 页码：3674-3678
- 全文大小：380K
- 年卷期：0
- ISSN：2155-5435
文摘
A facile, copper-catalyzed aminoarylation reaction of various aryl/alkyl alkynes was realized by utilizing N-fluoroarylsulfonimides (NFSI) as aminoarylation or amination reagent with hydroxyl as directing group. With this methodology, various α,β-unsaturated carbonyl compounds and indenones were efficiently constructed, and the synthetic application for indole derivatives was also provided. The aminoarylation reactions operate via a regiospecific addition of copper-coordinated nitrogen radical to C–C triple bond/Cvinyl–Caryl bond formation followed by other series of radical processes.