Amine-Functionalized Lanthanide-Doped KGdF4 Nanocrystals as Potential Optical/Magnetic Multimodal Bioprobes

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• 作者：Qiang Ju ; Datao Tu ; Yongsheng Liu ; Renfu Li ; Haomiao Zhu ; Jincan Chen ; Zhuo Chen ; Mingdong Huang ; Xueyuan Chen
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：January 18, 2012
• 年：2012
• 卷：134
• 期：2
• 页码：1323-1330
• 全文大小：462K
• 年卷期：v.134,no.2(January 18, 2012)
• ISSN：1520-5126

文摘

Amine-functionalized lanthanide-doped KGdF₄ nanocrystals, synthesized via a facile one-step solvothermal route by employing polyethylenimine as the surfactant and capping ligand, have been demonstrated to be sensitive time-resolved FRET bioprobes to detect a trace amount of biomolecules such as avidin at a concentration of 5.5 nM and to be potential T₁-MRI contrast agents due to a large longitudinal relaxivity of Gd³⁺ (5.86 S^鈥?路mM^鈥? per Gd ion and 3.99 脳 10⁵ S^鈥?路mM^鈥? per nanocrystal).