Diterpenoids of the Cassane Type from Caesalpinia decapetala

详细信息    查看全文

• 作者：Yuben Qiao ; Qianqian Xu ; Zhengxi Hu ; Xiao-Nian Li ; Ming Xiang ; Junjun Liu ; Jinfeng Huang ; Hucheng Zhu ; Jianping Wang ; Zengwei Luo ; Yongbo XueYonghui Zhang
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：December 23, 2016
• 年：2016
• 卷：79
• 期：12
• 页码：3134-3142
• 全文大小：447K
• ISSN：1520-6025

文摘

Eighteen compounds, including eight new cassane-type furanoditerpenoids, 3β-hydroxyphanginin H (1), 3β-acetoxyphanginin H (2), 7β-acetoxyphanginin H (3), 7β-hydroxyphanginin H (4), 4-epi-3β-hydroxycaesalpinilinn (5), 4-epi-3β-acetoxycaesalpinilinn (6), 20-acetoxytaepeenin D (7), and tomocin E (8), along with 10 known compounds (9–18) were isolated from the roots of Caesalpinia decapetala. Compounds 1–13 were isolated from C. decapetala for the first time. The new compounds with their absolute configurations were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compounds 1, 4, 5, 7, and 11 exhibited inhibitory activities against the SW1990 human pancreatic cancer cell line with IC₅₀ values ranging from 2.9 to 8.9 μM.