Isolation and Structural Elucidation of Proline-Containing Cyclopentapeptides from an Endolichenic Xylaria sp.
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- 作者：Wen Wu ; Huanqin Dai ; Li Bao ; Biao Ren ; Jingcai Lu ; Yuanming Luo ; Liangdong Guo ; Lixin Zhang ; Hongwei Liu
- 刊名：Journal of Natural Products
- 出版年：2011
- 出版时间：May 27, 2011
- 年：2011
- 卷：74
- 期：5
- 页码：1303-1308
- 全文大小：759K
- 年卷期：v.74,no.5(May 27, 2011)
- ISSN：1520-6025
文摘
Two new cyclic pentapeptides (1 and 2) and the known blazein (3), ganodesterone (4), ergosterin (5), cerevisterol (6), 24-methylcholesta-4,6,8(14),22-tetraen-3-one (7), 5,8-epidioxyergosta-6,22-dien-3-ol (8), 16-伪-d-mannopyranosyloxyisopimar-7-en-19-oic acid (9), and 16-hydroxy isopimar-7-en-19-oic acid (10) have been isolated from the crude extract of an endolichenic Xylaria sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. The absolute configurations of 1 and 2 were assigned using Marfey鈥檚 method on their acid hydrolysate. Compounds 1鈭?b>10 were evaluated for activity against fungi and for synergistic antifungal activity. Compound 1 showed synergistic antifungal activity against Candida albicans SC5314 with 0.004 渭g/mL ketoconazole.