Real-Time Monitoring in Vivo Behaviors of Theranostic Nanoparticles by Contrast-Enhanced T1 Imaging

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• 作者：Xianglong Zhu ; Xiaoqin Chi ; Jiahe Chen ; Lirong Wang ; Xiaomin Wang ; Zhong Chen ; Jinhao Gao
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：September 1, 2015
• 年：2015
• 卷：87
• 期：17
• 页码：8941-8948
• 全文大小：540K
• ISSN：1520-6882

文摘

The innovative applications of engineered nanoparticles (NPs) in medicine, such as diagnosis and therapy, have attracted considerable attention. It is highly important to predict the interactions between engineered NPs and the complex biological system as well as the impacts on the subsequent behaviors in living subjects. Herein, we report the use of T₁ contrast-enhanced magnetic resonance imaging (MRI) to monitor the in vivo behaviors of NPs in a real-time manner. We chose ultrasmall Pd nanosheets (SPNSs) as the object of NPs because of their promise in theranostics and fitness for diverse surface chemistry. SPNSs were modified with different surface coating ligands (e.g., polyethylene glycol, zwitterionic ligands, polyethylenimine) and functionalized with Gd-chelates to render T₁ contrast-enhanced capability. MRI real-time monitoring recorded the location and accumulation of SPNSs in small animals and revealed the prominent roles of surface coating ligands in pharmacokinetics. These results highlighted the significance of selecting proper surface coating for particular biomedical assignment. Moreover, we demonstrated a powerful and noninvasive means to predict and detect the behaviors of NPs in living subjects, which may be helpful for rational design and screening of engineered NPs in biomedical applications.