Intracellular Spatial Control of Fluorescent Magnetic Nanoparticles

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• 作者：Jinhao Gao ; Wei Zhang ; Pingbo Huang ; Bei Zhang ; Xixiang Zhang ; Bing Xu
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：March 26, 2008
• 年：2008
• 卷：130
• 期：12
• 页码：3710 - 3711
• 全文大小：214K
• 年卷期：v.130,no.12(March 26, 2008)
• ISSN：1520-5126

文摘

We report a facile intracellular manipulation of fluorescent magnetic Fe₃O₄-CdSe nanoparticles using magnetic force. The growth of CdSe quantum dots on Fe₃O₄ nanoparticles produces Fe₃O₄-CdSe nanoparticles with two distinct properties, fluorescence and superparamagnetism. After nonspecific surface modification using glutathione (GSH), the hydrophilic Fe₃O₄-CdSe@GSH nanoparticles can be easily uptaken by an HEK293T cell line. Confocal images indicate that the uptaken nanoparticles can be manipulated using a small magnet. The successful intracellular manipulation of magnetic nanoparticles may offer a new strategy for studying polarized cells.