Cyclic Tripeptides from the Halotolerant Fungus Aspergillus sclerotiorum PT06-1

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• 作者：Jinkai Zheng ; Zhihong Xu ; Yi Wang ; Kui Hong ; Peipei Liu ; Weiming Zhu
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：June 25, 2010
• 年：2010
• 卷：73
• 期：6
• 页码：1133-1137
• 全文大小：165K
• 年卷期：v.73,no.6(June 25, 2010)
• ISSN：1520-6025

文摘

Eleven new aspochracin-type cyclic tripeptides, sclerotiotides A−K (1−11), together with three known compounds, JBIR-15 (12), aspochracin (13), and penicillic acid, were isolated from the ethyl acetate extract of the fermentation broth of the halotolerant Aspergillus sclerotiorum PT06-1 in a hypersaline nutrient-rich medium. Their structures were elucidated by spectroscopic analysis and chemical methods. Chemical transformations of 12 and 13 proved that sclerotiotides D−K (4−11) were artifacts probably formed during the fermentation or subsequent isolation steps. All 13 cyclic tripeptides have been evaluated for their antimicrobial and cytotoxic effects. Only sclerotiotides A (1), B (2), F (6), and I (9) and JBIR-15 (12) showed selective antifungal activity against Candida albicans with MIC values of 7.5, 3.8, 30, 6.7, and 30 μM, respectively.