Highly Sensitive Ammonia Sensor with Organic Vertical Nanojunctions for Noninvasive Detection of Hepatic Injury

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• 作者：Ming-Zhi Dai ; Yi-Lo Lin ; Hung-Cheng Lin ; Hsiao-Wen Zan ; Kai-Ting Chang ; Hsin-Fei Meng ; Jiunn-Wang Liao ; May-Jywan Tsai ; Henrich Cheng
• 刊名：Analytical Chemistry
• 出版年：2013
• 出版时间：March 19, 2013
• 年：2013
• 卷：85
• 期：6
• 页码：3110-3117
• 全文大小：446K
• 年卷期：v.85,no.6(March 19, 2013)
• ISSN：1520-6882

文摘

We successfully demonstrate the first solid-state sensor to have reliable responses to breath ammonia of rat. For thioacetamide (TAA)-induced hepatopathy rats, we observe that the proposed sensor can detect liver that undergoes acute鈥搈oderate hepatopathy with a p-value less than 0.05. The proposed sensor is an organic diode with vertical nanojunctions produced by using low-cost colloidal lithography. Its simple structure and low production cost facilitates the development of point-of-care technology. We also anticipate that the study is a starting point for investigating sophisticated breath-ammonia-related disease models.