Fluorescent Bioactive Corrole Grafted-Chitosan Films

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• 作者：Joana F. B. Barata ; Ricardo J. B. Pinto ; Vanda I. R. C. Vaz Serra ; Armando J. D. Silvestre ; Tito Trindade ; Maria Graça P. M. S. Neves ; José A. S. Cavaleiro ; Sara Daina ; Patrizia Sadocco ; Carmen S. R. Freire
• 刊名：Biomacromolecules
• 出版年：2016
• 出版时间：April 11, 2016
• 年：2016
• 卷：17
• 期：4
• 页码：1395-1403
• 全文大小：563K
• 年卷期：0
• ISSN：1526-4602

文摘

Transparent corrole grafted-chitosan films were prepared by chemical modification of chitosan with a corrole macrocycle, namely, 5,10,15-tris(pentafluorophenyl)corrole (TPFC), followed by solvent casting. The obtained films were characterized in terms of absorption spectra (UV–vis), FLIM (fluorescence lifetime imaging microscopy), structure (FTIR, XPS), thermal stability (TGA), thermomechanical properties (DMA), and antibacterial activity. The results showed that the chemical grafting of chitosan with corrole units did not affect its film-forming ability and that the grafting yield increased with the reaction time. The obtained transparent films presented fluorescence which increases with the amount of grafted corrole units. Additionally, all films showed bacteriostatic effect against S. aureus, as well as good thermomechanical properties and thermal stability. Considering these features, promising applications may be envisaged for these corrole-chitosan films, such as biosensors, bioimaging agents, and bioactive optical devices.