Discovery of Lucensimycins A and B from Streptomyces lucensis MA7349 Using an Antisense Strategy

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• 作者：Sheo B. Singh ; Deborah L. Zink ; Joanne Huber ; Olga Genilloud ; Oscar Salazar ; M. Teresa Diez ; Angela Basilio ; Francisca Vicente ; Kevin M. Byrne
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：November 23, 2006
• 年：2006
• 卷：8
• 期：24
• 页码：5449 - 5452
• 全文大小：82K
• 年卷期：v.8,no.24(November 23, 2006)
• ISSN：1523-7052

文摘

Inhibition of protein synthesis is one of the validated and highly successful targets for inhibition of bacterial growth; this mechanism is atarget of a large number of clinical drugs. Ribosomal protein S4, a primary protein, is a potential target for the discovery of antibacterialagents. We describe, using an antisense-sensitized rpsD Streptomyces aureus strain, the discovery and activity of lucensimycins A and B.