Large-Scale Carbonyl Reductions in the Pharmaceutical Industry

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• 作者：Javier Magano ; Joshua R. Dunetz
• 刊名：Organic Process Research & Development
• 出版年：2012
• 出版时间：June 15, 2012
• 年：2012
• 卷：16
• 期：6
• 页码：1156-1184
• 全文大小：1636K
• 年卷期：v.16,no.6(June 15, 2012)
• ISSN：1520-586X

文摘

Herein we present a review on methods for carbonyl reductions on large scale (鈮?00 mmol) applied to the synthesis of drug candidates in the pharmaceutical industry. We discuss the most common and reliable methods for the reduction of aldehydes, ketones, carboxylic acids, esters, amides, imides, and acid chlorides. Representative examples illustrate detailed reaction and workup conditions and highlight the advantages and limitations of each reducing agent with special emphasis on safety, cost, and amenability to scale-up.