Supramolecular Guest鈥揌ost Interactions for the Preparation of Biomedical Materials

详细信息    查看全文

• 作者：Christopher B. Rodell ; Joshua E. Mealy ; Jason A. Burdick
• 刊名：Bioconjugate Chemistry
• 出版年：2015
• 出版时间：December 16, 2015
• 年：2015
• 卷：26
• 期：12
• 页码：2279-2289
• 全文大小：444K
• ISSN：1520-4812

文摘

Supramolecular chemistry has emerged as an important technique for the formation of biomaterials, including nano- and microparticles and hydrogels. One specific class of supramolecular chemistry is the direct association of guest鈥揾ost pairs, which involves host macrocycles such as cyclodextrins and cucurbit[n]urils and a wide range of guest molecules, where association is typically driven by molecule size and hydrophobicity. These systems are of particular interest in the biomedical field due to their dynamic nature, chemical diversity, relative ease of synthesis, and ability to interact with biological or synthetic molecules. In this review, we discuss aspects of polymeric material assembly mediated by guest鈥揾ost interactions, including the fundamentals of assembly into functional biomedical materials. Additionally, applications of biomaterials that utilize guest鈥揾ost interactions are discussed with a focus on injectable material formulations, the sequestration and delivery of encapsulated cargo (i.e., drugs, biomolecules), and the investigation of cell鈥搈aterial interactions (i.e., adhesion, differentiation, and delivery). While methodologies for guest鈥揾ost mediated assembly and biological interaction have rapidly evolved in recent years, they remain far from realizing their full potential in the biomaterials field.