Iron(I) in Negishi Cross-Coupling Reactions
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- 作者：Christopher J. Adams ; Robin B. Bedford ; Emma Carter ; Nicholas J. Gower ; Mairi F. Haddow ; Jeremy N. Harvey ; Michael Huwe ; M. 脕ngeles Cartes ; Stephen M. Mansell ; Carla Mendoza ; Damien M. Murphy ; Emily C. Neeve ; Joshua Nunn
- 刊名：The Journal of the American Chemical Society
- 出版年：2012
- 出版时间：June 27, 2012
- 年：2012
- 卷：134
- 期：25
- 页码：10333-10336
- 全文大小：266K
- 年卷期：v.134,no.25(June 27, 2012)
- ISSN：1520-5126
文摘
Herein we demonstrate both the importance of Fe(I) in Negishi cross-coupling reactions with arylzinc reagents and the isolation of catalytically competent Fe(I) intermediates. These complexes, [FeX(dpbz)2] [X = 4-tolyl (7), Cl (8a), Br (8b); dpbz = 1,2-bis(diphenylphosphino)benzene], were characterized by crystallography and tested for activity in representative reactions. The complexes are low-spin with no significant spin density on the ligands. While complex 8b shows performance consistent with an on-cycle intermediate, it seems that 7 is an off-cycle species.