Plasmonic Nanosensors for the Determination of Drug Effectiveness on Membrane Receptors

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• 作者：Rubén Ahijado-GuzmánJulia Menten ; Janak Prasad ; Christina Lambertz ; Germán Rivas ; Carsten Sönnichsen
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2017
• 出版时间：January 11, 2017
• 年：2017
• 卷：9
• 期：1
• 页码：218-223
• 全文大小：427K
• ISSN：1944-8252

文摘

We demonstrate the potential of the NanoSPR (nanoscale surface plasmon resonance sensors) method as a simple and cheap tool for the quantitative study of membrane protein–protein interactions. We use NanoSPR to determine the effectiveness of two potential drug candidates that inhibit the protein complex formation between FtsA and ZipA at initial stages of bacterial division. As the NanoSPR method relies on individual gold nanorods as sensing elements, there is no need for fluorescent labels or organic cosolvents, and it provides intrinsically high statistics. NanoSPR could become a powerful tool in drug development, drug delivery, and membrane studies.