Synthesis of (鈭?-伪-Kainic Acid via TMSCl-Promoted Pd-Catalyzed Zinc-ene Cyclization of an Allyl Acetate

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• 作者：Guoqing Wei ; Justin M. Chalker ; Theodore Cohen
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：October 7, 2011
• 年：2011
• 卷：76
• 期：19
• 页码：7912-7917
• 全文大小：817K
• 年卷期：v.76,no.19(October 7, 2011)
• ISSN：1520-6904

文摘

A highly practical synthesis of enantiopure (鈭?-伪-kainic acid is accomplished in 37% overall yield, using 13 linear steps and a minimum of chromatographic separations via an unprecedented TMSCl-promoted palladium-catalyzed zinc-ene cyclization of an allyl acetate.