Copper-Catalyzed 纬-Sulfonylation of 伪,尾-Unsaturated Carbonyl Compounds by Means of Silyl Dienol Ethers

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• 作者：Xiaoguang Liu ; Xiaohong Chen ; Justin T. Mohr
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：July 17, 2015
• 年：2015
• 卷：17
• 期：14
• 页码：3572-3575
• 全文大小：374K
• ISSN：1523-7052

文摘

A regioselective method for the introduction of sulfonyl groups at the 纬-carbon of enone systems is reported. Using a copper catalyst and readily available sulfonyl chlorides, a range of silyl dienol ethers are sulfonylated in good yield under mild reaction conditions. The sulfone derivatives formed are poised for further synthetic manipulations as demonstrated by regioselective alkylations.