Hypoxia-Sensitive Fluorescent Probes for in Vivo Real-Time Fluorescence Imaging of Acute Ischemia
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- 作者：Kazuki Kiyose ; Kenjiro Hanaoka ; Daihi Oushiki ; Tomomi Nakamura ; Mayumi Kajimura ; Makoto Suematsu ; Hiroaki Nishimatsu ; Takehiro Yamane ; Takuya Terai ; Yasunobu Hirata ; Tetsuo Nagano
- 刊名：Journal of the American Chemical Society
- 出版年：2010
- 出版时间：November 17, 2010
- 年：2010
- 卷：132
- 期：45
- 页码：15846-15848
- 全文大小：158K
- 年卷期：v.132,no.45(November 17, 2010)
- ISSN：1520-5126
文摘
Based on the findings that the azo functional group has excellent properties as the hypoxia-sensor moiety, we developed hypoxia-sensitive near-infrared fluorescent probes in which a large fluorescence increase is triggered by the cleavage of an azo bond. The probes were used for fluorescence imaging of hypoxic cells and real-time monitoring of ischemia in the liver and kidney of live mice.