Development of Iron-Doped Silicon Nanoparticles As Bimodal Imaging Agents

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• 作者：Mani P. Singh ; Tonya M. Atkins ; Elayaraja Muthuswamy ; Saeed Kamali ; Chuqiao Tu ; Angelique Y. Louie ; Susan M. Kauzlarich
• 刊名：ACS Nano
• 出版年：2012
• 出版时间：June 26, 2012
• 年：2012
• 卷：6
• 期：6
• 页码：5596-5604
• 全文大小：518K
• 年卷期：v.6,no.6(June 26, 2012)
• ISSN：1936-086X

文摘

We demonstrate the synthesis of water-soluble allylamine-terminated Fe-doped Si (Si_xFe) nanoparticles as bimodal agents for optical and magnetic imaging. The preparation involves the synthesis of a single-source iron-containing precursor, Na₄Si₄ with x% Fe (x = 1, 5, 10), and its subsequent reaction with NH₄Br to produce hydrogen-terminated Si_xFe nanoparticles. The hydrogen-capped nanoparticles are further terminated with allylamine via thermal hydrosilylation. Transmission electron microscopy indicates that the average particle diameter is 3.0 卤 1.0 nm. The Si_5Fe nanoparticles show strong photoluminescence quantum yield in water (10%) with significant T₂ contrast (r₂/r₁ value of 4.31). Electron paramagnetic resonance and M枚ssbauer spectroscopies indicate that iron in the nanoparticles is in the +3 oxidation state. Analysis of cytotoxicity using the resazurin assay on HepG2 liver cells indicates that the particles have minimal toxicity.

Keywords:

silicon nanoparticles; water-soluble; thermal hydrosilylation bimodal imaging agents; iron doping; hepatocytes; cytotoxicity; resazurin assay