Structures of Pahayokolides A and B, Cyclic Peptides from a Lyngbya sp.
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- 作者：Tianying An ; Thallapuranam Krishnaswamy Suresh Kumar ; Minglei Wang ; Li Liu ; Jackson O. Lay ; Jr. ; Rohana Liyanage ; John Berry ; Miroslav Gantar ; Vered Marks ; Robert E. Gawley ; Kathleen S. Rein
- 刊名：Journal of Natural Products
- 出版年：2007
- 出版时间：May 2007
- 年：2007
- 卷：70
- 期：5
- 页码：730 - 735
- 全文大小：119K
- 年卷期：v.70,no.5(May 2007)
- ISSN：1520-6025
文摘
The isolation and structure elucidation of two cyclic peptides, pahayokolides A (1) and B (2), is described. Structuralfeatures determined for these compounds include a pendent N-acetyl-N-methyl leucine, both E- and Z-dehydrobutyrines,a homophenylalanine, and an unusual polyhydroxy amino acid that is most likely of mixed polyketide synthase/nonribosomal peptide synthase origin. These peptides were purified from a new species of cyanobacteria of the genusLyngbya, which was isolated from a periphyton mat from the Florida Everglades.