• 作者：Kengo Akagawa ; Hajime Akabane ; Seiji Sakamoto ; Kazuaki Kudo
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：May 15, 2008
• 年：2008
• 卷：10
• 期：10
• 页码：2035 - 2037
• 全文大小：369K
• 年卷期：v.10,no.10(May 15, 2008)
• ISSN：1523-7052

A resin-supported N-terminal prolyl peptide having a β-turn motif and hydrophobic polyleucine chain effectively catalyzed the asymmetric transfer hydrogenation under aqueous conditions. The polyleucine tether provides a hydrophobic cavity in aqueous media that brought about a remarkable acceleration of the reaction. In addition, the polyleucine chain also turned out to be essential for high enantioselectivity.