Sensitive Monitoring of Volatile Chemical Warfare Agents in Air by Atmospheric Pressure Chemical Ionization Mass Spectrometry with Counter-Flow Introduction

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• 作者：Yasuo Seto ; Mieko Kanamori-Kataoka ; Koichiro Tsuge ; Isaac Ohsawa ; Kazumitsu Iura ; Teruo Itoi ; Hiroyuki Sekiguchi ; Koji Matsushita ; Shigeharu Yamashiro ; Yasuhiro Sano ; Hiroshi Sekiguchi ; Hisashi Maruko ; Yasuo Takayama ; Ryoji Sekioka ; Akihiko Okumura ; Yasuaki Takada ; Hisashi Nagano ; Izumi Waki ; Naoya Ezawa ; Hiroyuki Tanimoto ; Shigeru Honjo ; Masumi Fukano ; Hidehiro Okada
• 刊名：Analytical Chemistry
• 出版年：2013
• 出版时间：March 5, 2013
• 年：2013
• 卷：85
• 期：5
• 页码：2659-2666
• 全文大小：329K
• 年卷期：v.85,no.5(March 5, 2013)
• ISSN：1520-6882

文摘

A new method for sensitively and selectively detecting chemical warfare agents (CWAs) in air was developed using counter-flow introduction atmospheric pressure chemical ionization mass spectrometry (MS). Four volatile and highly toxic CWAs were examined, including the nerve gases sarin and tabun, and the blister agents mustard gas (HD) and Lewisite 1 (L1). Soft ionization was performed using corona discharge to form reactant ions, and the ions were sent in the direction opposite to the airflow by an electric field to eliminate the interfering neutral molecules such as ozone and nitrogen oxide. This resulted in efficient ionization of the target CWAs, especially in the negative ionization mode. Quadrupole MS (QMS) and ion trap tandem MS (ITMS) instruments were developed and investigated, which were movable on the building floor. For sarin, tabun, and HD, the protonated molecular ions and their fragment ions were observed in the positive ion mode. For L1, the chloride adduct ions of L1 hydrolysis products were observed in negative ion mode. The limit of detection (LOD) values in real-time or for a 1 s measurement monitoring the characteristic ions were between 1 and 8 渭g/m³ in QMS instrument. Collision-induced fragmentation patterns for the CWAs were observed in an ITMS instrument, and optimized combinations of the parent and daughter ion pairs were selected to achieve real-time detection with LOD values of around 1 渭g/m³. This is a first demonstration of sensitive and specific real-time detection of both positively and negatively ionizable CWAs by MS instruments used for field monitoring.