Utility of Dysprosium as a Reductant in Coupling Reactions of Acyl Chlorides: The Synthesis of Amides and Diaryl-Substituted Acetylenes

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• 作者：Weifeng Chen ; Kebin Li ; Ziqiang Hu ; Liliang Wang ; Guoqiao Lai ; Zhifang Li
• 刊名：Organometallics
• 出版年：2011
• 出版时间：April 11, 2011
• 年：2011
• 卷：30
• 期：7
• 页码：2026-2030
• 全文大小：782K
• 年卷期：v.30,no.7(April 11, 2011)
• ISSN：1520-6041

文摘

Reduction of acyl chlorides with dysprosium metal has been studied. The reducing ability of dysprosium metal is solvent-dependent. Dysprosium metal, which requires neither any additive nor pretreatment, can promote the cross-coupling of acyl chlorides in DMF or DEF to give amides in good yields. When the reaction was performed in N,N-dimethylacetamide, the reductive self-coupling reaction of aroyl chloride took place smoothly and afforded the diaryl-substituted acetylenes in moderate to good yield.