Kinetic Resolution of 尾-Substituted Olefinic Carboxylic Acids by Asymmetric Bromolactonization

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• 作者：Kenichi Murai ; Tomoyo Matsushita ; Akira Nakamura ; Norimichi Hyogo ; Junki Nakajima ; Hiromichi Fujioka
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：May 17, 2013
• 年：2013
• 卷：15
• 期：10
• 页码：2526-2529
• 全文大小：260K
• 年卷期：v.15,no.10(May 17, 2013)
• ISSN：1523-7052

文摘

A strategically novel kinetic resolution of 尾-substituted olefinic carboxylic acids is developed by asymmetric bromolactonization using an organocatalyst, 4-tBuPh-tris 1b. The cyclization stage, which provides 未-lactone, is proposed to be operative for discrimination of each enantiomer of carboxylic acids.