Practical Alternative Synthesis of 1-(8-Fluoro-naphthalen-1-yl)piperazine

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• 作者：Zhijian Zhu ; Norm L. Colbry ; Mark Lovdahl ; Kenneth E. Mennen ; Alison Acciacca ; Vladimir G. Beylin ; Jerry D. Clark ; Daniel T. Belmont
• 刊名：Organic Process Research & Development
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：11
• 期：5
• 页码：907 - 909
• 全文大小：83K
• 年卷期：v.11,no.5(September 2007)
• ISSN：1520-586X

文摘

Convergent synthesis of 8-fluoronaphthalen-1-ylamine (6) was achieved through the reaction of 1H-naphtho[1,8-de][1,2,3]triazine (15) with HF-pyridine under mild conditions. This new synthesis for the preparation of 6 overcame many scale-up challenges that exist in the methods reported in the literature and provided a practical alternative synthesis of 1-(8-fluoronaphthalen-1-yl)piperazine (1).