Isolation, Structural Elucidation, and Synthesis of Lepteridine From Ma̅nuka (Leptospermum scoparium) Honey
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- 作者：Benjamin J. Daniels ; Gordana Prijic ; Sarah Meidinger ; Kerry M. Loomes ; Jonathan M. Stephens ; Ralf C. Schlothauer ; Daniel P. Furkert ; Margaret A. Brimble
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2016
- 出版时间：June 22, 2016
- 年：2016
- 卷：64
- 期：24
- 页码：5079-5084
- 全文大小：298K
- 年卷期：0
- ISSN：1520-5118
文摘
Ma̅nuka honey, made from the nectar of Leptospermum scoparium, has garnered scientific and economical interest due to its nonperoxide antibacterial activity. Biomarkers for genuine ma̅nuka honey are increasingly in demand due to the presence of counterfeit ma̅nuka honey. This work reports the identification of a compound previously unreported in ma̅nuka honey by HPLC, and determination of the structure of the as 3,6,7-trimethyllumazine using NMR, MS, IR, and UV/vis spectroscopy. This assignment was confirmed by total synthesis. The natural product, renamed lepteridine, was only observed in ma̅nuka honeys and could potentially serve as a biomarker for genuine ma̅nuka honey.